Copenhagen, Denmark – 08.01.2026 – RetinaLyze System A/S today announces the release of a groundbreaking new feature in the RetinaLyze software: 3D visualization of the optic nerve head morphology from standard 2D retinal images.
This innovation, based on the research recently published in BMJ Open Ophthalmology (2025), enables both optometrists and ophthalmologists to gain structural, perfusion-based insights previously accessible only through OCT.
How it works
The RetinaLyze Glaucoma module analyses the colour composition of the optic nerve head in a conventional fundus image to estimate local haemoglobin (Hb) distribution, a direct indicator of perfusion.
Using deep learning algorithms refined through analysis of over 1.1 million optic nerve images, the system reconstructs a 3D model of the optic disc and cup, showing the neuro-retinal rim and cup volume.
This means that from a simple 2D photo, the clinician can now visualize the shape and depth of the optic nerve and its changes over time.
Scientific validation
The study “Estimation of normal and glaucomatous optic nerve morphology from perfusion” (BMJ Open Ophthalmology, 2025) demonstrated that:
The correlation between local Hb density and OCT-measured tissue thickness was R = 0.953 (p < 0.0001).
The rim and cup volumes estimated by the RetinaLyze Glaucoma (known in research as Laguna ONhE) method showed a strong relationship with OCT-derived values (R = 0.786 and R = 0.762, respectively).
The relationship between perfusion and morphology was consistent across more than a million screening images provided by RetinaLyze System A/S.
The conclusion: “The volume and shape of the optic nerve tissue are closely related to its perfusion and can be deduced from it.”
Value for eye care professionals
For optometrists, RetinaLyze Glaucoma adds a new dimension to everyday eye screening:
Gain 3D insight from 2D images where OCT is not practical or feasible.
Monitor progression by comparing with historical images.
Support accurate referral decisions with clear visualization of optic nerve structure.
For ophthalmologists, it provides a quantitative structural and vascular perspective on glaucoma, complementing existing imaging tools and offering a quick way to assess perfusion-driven morphological change even in satellite clinics without OCT.
By linking function, perfusion, and structure, this innovation makes objective glaucoma analysis more accessible and consistent across all levels of eye care.
A bridge between screening and specialist care
With this 3D optic nerve visualization, we’re giving every optometrist access to morphological insights that previously required expensive instrumentationIt’s another step towards democratizing advanced glaucoma diagnostics and improving early detection, monitoring, and collaboration between optometrists and ophthalmologists.
About RetinaLyze System A/S
RetinaLyze System A/S develops AI-powered tools that support eye care professionals in detecting and managing vision-threatening diseases such as diabetic retinopathy, AMD, and glaucoma.
Its technology is used in more than 20 countries and supports millions of screenings each year.
For more information, visit www.retinalyze.com or contact hello@retinalyze.com.