Logo_white

Combined diagnostic accuracy of two artificial intelligence systems for glaucoma diagnosis using color fundus photography

PurposeTo evaluate the diagnostic accuracy of two commercially available artificial intelligence (AI) systems based on color fundus photography (CFP), the Laguna ONhE and VUNO Med-Fundus AI, for glaucoma detection, both independently and in combination. MethodsThis retrospective cross-sectional study included 370 eyes from 193 patients (248 eyes with primary open-angle glaucoma and 122 healthy eyes). All […]

Assessment of Structural Progression in Glaucoma Through Automated Optic Nerve Head Hemoglobin Measurements

Purpose‍To assess the performance of automated optic nerve head hemoglobin measurements (ONH Hb) for detection of structural progression in glaucoma patients using event analysis. Patients and Methods‍Treated glaucoma patients were included in this cross-sectional study. Two experienced examiners classified patients into progressors and non-progressors (controls) based on serial color retinographies (CR). Progressors were then subdivided […]

Estimation of normal and glaucomatous optic nerve morphology from perfusion

ObjectiveTo estimate the optic nerve head morphology from its haemoglobin (Hb) distribution. Methods and analysis‍The optic disc of 189 normal eyes and 292 with confirmed and suspected glaucoma were analysed with Spectralis-OCT and the Laguna ONhE application using the Topcon NW400 fundus camera. Topographic Hb values were correlated with OCT tissue thicknesses from Bruch’s membrane. […]

Frequency of the vertical cup-to-disc ratio to normal optical disc size

The relationship between the optic disc area and the vertical cup/disc ratio is presented by means of a graphic nomogram after studying a total of 365,356 normal optic nerves. For this purpose, the Laguna ONhE application was used, which analyses the distribution of hemoglobin based on the colorimetric analysis of fundus color images. The 1%, […]

Agreement between Five Experts and the Laguna ONhE Automatic Colourimetric Application Interpreting the Glaucomatous Aspect of the Optic Nerve

BackgroundOptic nerve head (ONH) interpretation is a glaucoma screening method which may be influenced by criteria variability. Laguna ONhE software (also known as RetinaLyze Glaucoma) is a low-cost and non-invasive method of ONH analysis. MethodsWe analysed the results of the Laguna ONhE application, interpreting 552 ONH images from the ACRIMA database, publicly available on the Internet, […]

Comparison of age-related vascular changes in the optic disc of patients with diabetes, with glaucomatous and non-glaucomatous features

Objective‍To identify age-related vascular changes in the optic discs of patients with diabetes with and without signs of glaucoma. ‍Methods and analysis‍A total of 2153 eyes of 1797 patients with diabetes without significant retinopathy were monitored with 10 Topcon-NW400 images obtained over 10.27±1.58 years. 571 non-diabetics eyes were selected as controls. Laguna ONhE uses convolutional […]

Discrimination Between Healthy Eyes and Those With Mild Glaucoma Damage Using Hemoglobin Measurements of the Optic Nerve Head

PrécisThe Laguna ONhE, a software that measures the hemoglobin (Hb) concentration of the optic nerve head (ONH) from fundus photographs, demonstrated good accuracy in discriminating healthy eyes from eyes with mild glaucoma. Purpose The aim was to evaluate Hb concentration of the optic nerve to distinguish between healthy eyes and eyes with mild glaucoma. MethodsEyes […]

Optic disc area frequency distribution in a large sample of retinographic images

Objective‍To describe a new method to estimate the frequency distribution of optic nerve disc area, using digital retinographic images. ‍Methods and analysis‍We analysed 492 023 fundus images obtained with seven fundus cameras, mainly in Caucasian subjects. They were grouped by resolution and zoom. They were automatically segmented by identifying the inner edge of the Elschnig […]

Optic Nerve Head Hemoglobin Levels in Glaucoma: A Structural and Functional Correlation Study

PurposeTo investigate structural and functional correlations in glaucoma patients using optic nerve head hemoglobin (ONH Hb) measurements as determined by automated colorimetric analysis of conventional retinography. MethodsWe prospectively enrolled healthy participants and glaucomatous patients with a wide range of disease stages. All participants underwent visual field (VF) testing (standard automated perimetry, SAP), color fundus imaging […]

Fully Automated Colorimetric Analysis of the Optic Nerve Aided by Deep Learning and Its Association with Perimetry and OCT for the Study of Glaucoma

BackgroundLaguna-ONhE is an application for the colorimetric analysis of optic nerve images, which topographically assesses the cup and the presence of haemoglobin. Its latest version has been fully automated with five deep learning models. In this paper, perimetry in combination with Laguna-ONhE or Cirrus-OCT was evaluated. MethodsThe morphology and perfusion estimated by Laguna ONhE were […]

New gip index for progression analysis, ussing the laguna ohne method for the optic nerve head hemoglobin evaluation

PurposeLaguna ONhE automatically analyzes hemoglobin distribution in optic disc retinographies (1-9). Its main index, called GDF (Globin Distribution Factor) involves a classifier based on Deep Learning that tends to produce extreme values: (1=normal, 0=glaucoma). The consequence is a good detection performance, outweighed by certain variability in the limit range between normality and glaucoma. Therefore, its […]

Fully automated Deep Learning analysis of hemoglobin images of the optic nerve associated with perimetry for the study of glaucoma

Purpose‍Colorimetric analysis of optic nerve images for assessing their hemoglobin distribution (Laguna ONhE) (1-4) is tested in combination with perimetry. Methods‍Deep learning training was used to identify nerve edges, laterality of the eye, image quality, vessel segmentation and classification (normal vs glaucoma). Data was compiled into a “Globin Distribution Function” (GDF), which was also associated […]

Glaucoma screening in 285,320 optic disc color images using laguna onhe hemoglobin distribution analysis

Purpose‍To assess a mass screening in general population, mainly European, using the Laguna ONhE system to detect glaucoma.‍ Methods‍285,320 retinographies obtained in numerous locations with various fundus cameras were analyzed fully automatically and unsupervised via Internet, between January 2019 and December 2020. Deep Learning was used for identifying the eye (left or right), segmenting the […]

Diagnostic validity of optic nerve head colorimetric assessment and optical coherence tomography angiography in patients with glaucoma

PurposeThe aim of this study was to assess the optic nerve head (ONH) and macular vessel density with optical coherence tomography angiography (OCT-A) and the ONH haemoglobin (ONH Hb) amount with Laguna ONhE program in open-angle glaucoma (OAG) patients. MethodsIn this prospective observational cross-sectional study, 67 OAG patients and 41 healthy age-sex frequency matched subjects […]

Segmentation of the Optic Nerve Head Based on Deep Learning to Determine its Hemoglobin Content in Normal and Glaucomatous Subjects

PurposeTo determine the limits of the optic nerve head (ONH) in color fundus images using Deep learning (DL) for the estimation of its hemoglobin topographic distribution. Also, to evaluate the usefulness of that distribution in glaucoma diagnosis singly or in association with perimetry.‍ Methods‍A DL method was trained using 40000 fundus images and applied to […]

Hemoglobin measurement in the optic nerve head using the Laguna ONhE program

PurposeThe Laguna ONhE program divides conventional color images of the optic nerve head (ONH) into 24 sectors using two ellipses, approximately parallel to its edge, and four diametrical lines. It notes the differences between its red and green components and compensates the diversities of spectral composition of the illumination light, the absorption of the lens […]

Relationship between Retinal Nerve Fiber Layer Thickness and Hemoglobin Present in the Optic Nerve Head in Glaucoma

PurposeTo observe the relationship between topographic hemoglobin levels in the optic nerve head (ONH), the rim thickness (BMO-MRW), and retinal nerve fiber layer (RNFL) thickness. Methods96 normal eyes and 82 glaucomas were examined using TOP strategy (Octopus 300 perimeter), SPECTRALIS OCT, and Laguna ONhE program which estimates hemoglobin from conventional color photographs (Horus Scope DEC […]

Preliminary study of differences in optic nerve head hemoglobin measures between childhood glaucoma patients and healthy volunteers

Purpose‍To evaluate the effectiveness of quantifying color changes in the optic nerve head in retinal photographs of patients with childhood glaucoma.‍ Methods‍In this observational study, three photographs of the optic nerve head were obtained in 28 patients with childhood glaucoma and 28 age- and sex-matched healthy participants (the childhood glaucoma and control groups, respectively). The […]

Reproducibility of the Laguna ONhE application with automatic segmentation of the limits of the optical nerve head, excavation and neuroretinal rim: Validation of new algorithms (Spanish)

PurposeTo compare the diagnostic accuracy and reproducibility of the Laguna ONhE program (with automatic segmentation of the optic nerve head cupping and neuro-retinal rim using new algorithms), with morphological (OCT) and functional (visual field) information. Methods96 healthy subjects and 82 glaucomas were examined twice with photographic images obtained with a fundus camera Horus Scope DEC-200 […]

Glaucoma diagnostic capacity of optic nerve head haemoglobin measures compared with spectraldomain OCT and HRT III confocal tomography

Similar diagnostic power for RetinaLyze Glaucoma, an OCT and a confocal tomography This study compares the diagnostic capacity of the RetinaLyze Glaucoma algorithm with that of spectral domain optical coherence tomography (OCT) and confocal tomography (HRT III) and found similar diagnostic power. PurposeThe computer program laguna onhe determines optic nerve head haemoglobin (ONH Hb) on […]

Reproducibility of Optic Nerve Head Hemoglobin Measures

PurposeTo evaluate intraobserver, interobserver, within-session and between-session reproducibility of the measurement of optic nerve head (ONH) hemoglobin levels by color analysis using Laguna ONhE [optic nerve hemoglobin (ONH Hb)] program. MethodsThis was an observational prospective study of 29 eyes (11 glaucomatous; 18 healthy eyes). Two examiners obtained 2 retinal photographs (Canon non-mydriatic retinal camera CD-DGi, […]

Estimating the Amount of Hemoglobin in the Neuroretinal Rim Using Color Images and OCT

The amount of Hb in the ONH has an important relationship with glaucomatous eyes This study assessed the amount of Hb (hemoglobin) in healthy and glaucomatous eyes. The amount of Hb in the ONH seems to have an important relationship with glaucomatous visual field sensitivity. PurposeTo calculate the amount of hemoglobin (Hb) in the optic […]

Optic Nerve Head hemoglobin levels in childhood glaucoma patients

PurposeThe computer program Laguna ONhE determines optic nerve head hemoglobin (ONH Hb) on retinal photographs based on detecting colour differences. The software provides two diagnostic indices for glaucoma: estimated vertical cup-disc-ratio (C/D) and glaucoma discriminant function GDF). This study examines the amount of ONH Hb in patients with chilhood glaucoma using this new noninvasive technique. […]

Correlating cup-to-disc ratios measured by HRT-III, SD-OCT and the new color imaging Laguna ONhE procedure (Spanish)

PurposeTo examine correlations between cup-to-disc (C/D) ratios determined by the new Laguna ONhE (optic nerve hemoglobin) color imaging procedure, spectral domain optical coherence tomography (OCT), confocal scanning laser tomography using Heidelberg retina tomography (HRT), and examining retinal images. MethodsC/D ratio measurements were made on 154 eyes of 154 subjects (52 healthy controls, 36 with ocular […]

Measuring Hemoglobin Levels in the Optic Nerve Head: Comparisons with Other Structural and Functional Parameters of Glaucoma

PurposeWe evaluated and compared the ability of a new method for measuring hemoglobin (Hb) levels at the optic nerve head (ONH) to that of visual field evaluation, scanning laser ophthalmoscopy (HRT), scanning laser polarimetry (GDx), and optical coherence tomography (OCT) for diagnosing glaucoma. MethodsHealthy eyes (n=102) and glaucomatous eyes (n=101) underwent reliable Oculus Spark perimetry, […]